FoxO3 Regulates Neural Stem Cell Homeostasis
نویسندگان
چکیده
منابع مشابه
FoxO3 regulates neural stem cell homeostasis.
In the nervous system, neural stem cells (NSCs) are necessary for the generation of new neurons and for cognitive function. Here we show that FoxO3, a member of a transcription factor family known to extend lifespan in invertebrates, regulates the NSC pool. We find that adult FoxO3(-/-) mice have fewer NSCs in vivo than wild-type counterparts. NSCs isolated from adult FoxO3(-/-) mice have decre...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2009
ISSN: 1934-5909
DOI: 10.1016/j.stem.2009.09.014